Description
Rabies virus (RABV), scientific name Rabies lyssavirus, is a deadly neurotropic virus that causes rabies in humans and animals.
Rabies virus has an extremely wide host range and its transmission most often occur through the saliva of animals.
Without intervention prior to disease progression, rabies has the highest case fatality of any infectious disease.
RABV contains a single-stranded negative-sense R genome that encodes five structural proteins: nucleoprotein (N), phosphoprotein (P), matrix protein (M), glycoprotein (G), and R-dependent R polymerase (L).
Among these viral proteins, the RABV glycoprotein (RABV-G) is a pivotal player mediating virus entry and the major target of neutralizing antibodies, thus a key factor for vaccine and drug design.
A rapid and effective assay kit detecting the levels ofRABV-G is urgently needed to accelerate the development of RABV vaccines